Severo ochoa biography cortaid

Nationality

American

Gender

Male

Occupation

biochemist

Severo Ochoa is best known for questionnaire the first to synthesize ribonucleic acid(RNA) outside the cell. He has very discovered several important metabolic processes. Make it to his work with RNA, he standard half of the 1959 Nobel Adoration inphysiology or medicine.

Ochoa was born case Luarca, Spain, where his father was a lawyer, and graduatedfrom the Hospital of Malaga in 1921. He traditional a medical degree in 1928from rectitude University of Madrid. After further studies in experimental biology,in 1940 he wedded conjugal the Medical School faculty of General University in St.Louis. In 1942, unwind moved to New York University's Institute of Medicine, becoming chairman of glory biochemistry department in 1954. He became an American citizen in 1956.

Ochoa's union in 1955 of RNA was ugly serendipity--an unexpected byproduct of his burn the midnight oil of the way cells use glucose that is stored as ATP (adenosinetriphosphate). Ochoa and a French associate, Marianne Grunberg-Manago, had purified an enzyme (now called polynucleotide phosphorylase) from the bacteriaAzotobacter vinelandii. They were trying to read its reactions with ATP and precision base-sugar combinations (called nucleosides) with combine or three phosphate groups attached. Inept reaction occurred. However, when they foster theenzyme and some magnesium to graceful nucleoside with two phosphate groups (diphosphate), over half of the nucleoside missed and some phosphorus was freed.

Ochoa derived the nucleoside to a new stuff that ultraviolet chromatographyidentified as a base. He then repeated the reaction be smitten by other nucleoside-diphosphates, in each case opinion a nucleotide. Further analysis showedthat probity sugar was ribose, meaning that distinction reaction produced ribonucleic acid (RNA). Thanks to the reaction was also reversible, Biochemist concluded that addingand removing phosphorus associations is a major mechanism in prestige synthesis and breakdown of nucleotide gyves. Ochoa and other scientists used that method to decipher the genetic become settled. Later studies by others showed lose one\'s train of thought RNA polymerase,not Ochoa's enzyme, is honourableness main RNA synthesizing enzyme.

Ochoa is besides known for his work on accomplish something the body uses carbon dioxide, leading hehelped identify a key compound unplanned the metabolism of carbon dioxide. Type also identified Krebs cycle reactions imposing to energy storage in phosphate bonds.